Peristera Paschou, Professor of Biological Sciences and Associate Dean for Higher Education and Strategic Initiatives for the College of Science, is the principal investigator for further study of the syndrome.
Basho leads several research collaborations around the world on Turrett. Her work is supported by the National Science Foundation, the National Institutes of Health, and the National Institute of Neurological Disorders and Stroke. Her previous work includes being a co-author on a groundbreaking 2017 study that was the first in the world to identify the risk genes for Tourette’s syndrome. In 2021, she led a study that discovered more about the common genetic basis of Tourette’s-related neurodevelopmental disorders.
This NIMH grant will allow for the largest neuroimaging and genetics studies of Tourette syndrome to date, according to Purdue. Her work will coordinate with that of geneticists, neurologists, psychiatrists, child psychiatrists, brain imaging experts, computer scientists and statisticians at 18 sites in nine countries.
Basho’s study will collect and analyze global genetic and brain MRI data to further research the neurobiology of Tourette’s syndrome. This research can identify biomarkers that will help customize individual treatments for different patients.
“This effort builds on previous progress made by the ENIGMA (Advancing Neuroimaging Genetics Through Meta-Analysis) consortium,” Purdue’s statement said. Leading members of the team include University of Southern California co-investigators Professors Paul Thompson and Neda Jahanshad, as well as Kevin Black at Washington University in St. Louis.
Tourette syndrome is characterized by sudden, repetitive movements or screeching sounds. Usually in childhood. While Tourette syndrome affects about 0.5-1% of the world’s population, coexisting conditions are also diagnosed in 90% of those cases. These conditions usually include obsessive-compulsive disorder. attention deficit hyperactivity disorder; autism spectrum disorders; Major depressive disorder and anxiety disorders, according to Purdue.
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“What we and others have shown recently is that this very high co-morbidity may, in fact, be due to a common genetic cause,” Basho said. “So some of the same genes play a role and lead to all of these symptoms. Understanding Tourette syndrome will also help us understand other disorders as well. that lie across the so-called impulsive-compulsive spectrum of phenotypes.”
There is currently no known specific cause of Tourette’s syndrome, but it has been attributed to multiple genetic differences and environmental factors. Current treatments include behavioral therapies and drugs.
Basho looks forward to the successes of this five-year research initiative.
We’ll have a much clearer picture of the parts of the brain that play a role in the symptoms of Tourette’s syndrome. And we will have a clearer picture of the genes that drive the brain abnormalities that underlie this disorder and its comorbidities…
She said, “All of this genetic work is intended to help reveal potential therapeutic targets, as well as help guide the diagnosis and management of any of these related disorders.” life for patients and their families. We do all this work for them.”